AustralieFrV1, Main, Exploration, bibRecord, 00C761

Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension

Identifieur interne : 00C761 ( Main/Exploration ); précédent : 00C760; suivant : 00C762

Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension

Auteurs : A. Castaigne [France] ; J. Chalmers [Australie] ; T. Morgan [Australie] ; C. Chastang [France] ; L. Feldmann [France] ; D. Guez [France]

Source :

Clinical and experimental hypertension : (1993) [ 1064-1963 ] ; 1999.

RBID : Pascal:99-0516720

Descripteurs français

Pascal (Inist)
- Hypertension artérielle, Voie orale, Antihypertenseur, Périndopril, Inhibiteur angiotensin converting enzyme, Indapamide, Diurétique, Dose faible, Traitement, Chimiothérapie, Association médicamenteuse, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- ACE inhibitor, Antihypertensive agent, Chemotherapy, Diuretic, Drug combination, Human, Hypertension, Indapamide, Low dose, Oral administration, Perindopril, Treatment.

Abstract

The efficacy and safety of 12 weeks treatment with an oral fixed low-dose perindopril 2 mg + indapamide 0.625 mg (Per/Ind) combination in elderly and very elderly patients (65-85 years) with mild to moderate systolic and diastolic hypertension (SDH) or isolated systolic hypertension (ISH) were investigated vs placebo. This trial was a multinational randomized double-blind study with doubling of active drug dosage in nonresponders. Intention to treat analysis was performed in 383 patients (age 72.4 years ; ISH 32%). 58.5% remained on their initial dosage. Per/Ind decreased supine diastolic and systolic blood pressure (sDBP/sSBP) by 13.2 ± 8.0 mm Hg and 22.5 ± 13.9 mm Hg (P <.0001) versus placebo - 7.3 ± 9.0 mm Hg and - 12.3 ± 15.2 mm Hg, respectively. In ISH (n = 123), Per/Ind decreased sSBP by 23.0 ± 11.8 mm Hg (P <.0001). Overall response and normotension rates was 81.3% with Per/Ind (P <.0001). Adverse event rates (including hypokalemia) were similarly low in both groups. Analysis in the over-75 year subgroup showed similar safety and efficacy results. Fixed low-dose Per/Ind is a safe and effective treatment of hypertension including isolated systolic hypertension in the elderly.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 006200
to stream PascalFrancis, to step Curation: 006E54
to stream PascalFrancis, to step Checkpoint: 006065
to stream Main, to step Merge: 00D778
to stream Main, to step Curation: 00C761

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension</title>
<author><name sortKey="Castaigne, A" sort="Castaigne, A" uniqKey="Castaigne A" first="A." last="Castaigne">A. Castaigne</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Henri Mondor</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Flinders Medical Center</s1>
<s2>Bedford Park</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Bedford Park</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgan, T" sort="Morgan, T" uniqKey="Morgan T" first="T." last="Morgan">T. Morgan</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Physiology, University of Melbourne</s1>
<s2>Parkville, Victoria</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Chastang, C" sort="Chastang, C" uniqKey="Chastang C" first="C." last="Chastang">C. Chastang</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department for Biostatistical and Medical Information, Hôpital Saint Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feldmann, L" sort="Feldmann, L" uniqKey="Feldmann L" first="L." last="Feldmann">L. Feldmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut de Recherches Internationales Servier</s1>
<s2>Courbevoie</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Courbevoie</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guez, D" sort="Guez, D" uniqKey="Guez D" first="D." last="Guez">D. Guez</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut de Recherches Internationales Servier</s1>
<s2>Courbevoie</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Courbevoie</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0516720</idno>
<date when="1999">1999</date>
<idno type="stanalyst">PASCAL 99-0516720 INIST</idno>
<idno type="RBID">Pascal:99-0516720</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">006200</idno>
<idno type="wicri:Area/PascalFrancis/Curation">006E54</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">006065</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">006065</idno>
<idno type="wicri:doubleKey">1064-1963:1999:Castaigne A:efficacy:and:safety</idno>
<idno type="wicri:Area/Main/Merge">00D778</idno>
<idno type="wicri:Area/Main/Curation">00C761</idno>
<idno type="wicri:Area/Main/Exploration">00C761</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension</title>
<author><name sortKey="Castaigne, A" sort="Castaigne, A" uniqKey="Castaigne A" first="A." last="Castaigne">A. Castaigne</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hôpital Henri Mondor</s1>
<s2>Créteil</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Flinders Medical Center</s1>
<s2>Bedford Park</s2>
<s3>AUS</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Bedford Park</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morgan, T" sort="Morgan, T" uniqKey="Morgan T" first="T." last="Morgan">T. Morgan</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Physiology, University of Melbourne</s1>
<s2>Parkville, Victoria</s2>
<s3>AUS</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Chastang, C" sort="Chastang, C" uniqKey="Chastang C" first="C." last="Chastang">C. Chastang</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department for Biostatistical and Medical Information, Hôpital Saint Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feldmann, L" sort="Feldmann, L" uniqKey="Feldmann L" first="L." last="Feldmann">L. Feldmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut de Recherches Internationales Servier</s1>
<s2>Courbevoie</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Courbevoie</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guez, D" sort="Guez, D" uniqKey="Guez D" first="D." last="Guez">D. Guez</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institut de Recherches Internationales Servier</s1>
<s2>Courbevoie</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Courbevoie</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
<wicri:noRegion>Institut de Recherches Internationales Servier</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical and experimental hypertension : (1993)</title>
<title level="j" type="abbreviated">Clin. exp. hypertens. : (1993)</title>
<idno type="ISSN">1064-1963</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical and experimental hypertension : (1993)</title>
<title level="j" type="abbreviated">Clin. exp. hypertens. : (1993)</title>
<idno type="ISSN">1064-1963</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ACE inhibitor</term>
<term>Antihypertensive agent</term>
<term>Chemotherapy</term>
<term>Diuretic</term>
<term>Drug combination</term>
<term>Human</term>
<term>Hypertension</term>
<term>Indapamide</term>
<term>Low dose</term>
<term>Oral administration</term>
<term>Perindopril</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle</term>
<term>Voie orale</term>
<term>Antihypertenseur</term>
<term>Périndopril</term>
<term>Inhibiteur angiotensin converting enzyme</term>
<term>Indapamide</term>
<term>Diurétique</term>
<term>Dose faible</term>
<term>Traitement</term>
<term>Chimiothérapie</term>
<term>Association médicamenteuse</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The efficacy and safety of 12 weeks treatment with an oral fixed low-dose perindopril 2 mg + indapamide 0.625 mg (Per/Ind) combination in elderly and very elderly patients (65-85 years) with mild to moderate systolic and diastolic  hypertension (SDH) or isolated systolic hypertension (ISH) were investigated vs placebo. This trial was a multinational randomized double-blind study with doubling of active drug dosage in nonresponders. Intention to treat analysis was performed in 383 patients (age 72.4 years ; ISH 32%). 58.5% remained on their initial dosage. Per/Ind decreased supine diastolic and systolic blood pressure (sDBP/sSBP) by 13.2 ± 8.0 mm Hg and 22.5 ± 13.9 mm Hg (P <.0001) versus placebo - 7.3 ± 9.0 mm Hg and - 12.3 ± 15.2 mm Hg, respectively. In ISH (n = 123), Per/Ind decreased sSBP by 23.0 ± 11.8 mm Hg (P <.0001). Overall response and normotension rates was 81.3% with Per/Ind (P <.0001). Adverse event rates (including hypokalemia) were similarly low in both groups. Analysis in the over-75 year subgroup showed similar safety and efficacy results. Fixed low-dose Per/Ind is a safe and effective treatment of hypertension including isolated systolic hypertension in the elderly.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Créteil</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Castaigne, A" sort="Castaigne, A" uniqKey="Castaigne A" first="A." last="Castaigne">A. Castaigne</name>
</region>
<name sortKey="Chastang, C" sort="Chastang, C" uniqKey="Chastang C" first="C." last="Chastang">C. Chastang</name>
<name sortKey="Feldmann, L" sort="Feldmann, L" uniqKey="Feldmann L" first="L." last="Feldmann">L. Feldmann</name>
<name sortKey="Guez, D" sort="Guez, D" uniqKey="Guez D" first="D." last="Guez">D. Guez</name>
</country>
<country name="Australie"><noRegion><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name>
</noRegion>
<name sortKey="Morgan, T" sort="Morgan, T" uniqKey="Morgan T" first="T." last="Morgan">T. Morgan</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C761 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00C761 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:99-0516720
   |texte=   Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension

Efficacy and safety of an oral fixed low-dose perindopril 2 mg/indapamide 0.625 mg combination : A randomized, double-blind, placebo-controlled study in elderly patients with mild to moderate hypertension

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri